Pomegranate extracts have been known to be useful against viruses such as “influenza virus, herpes virus, poxviruses, and human immunodeficiency virus,” the researchers state. Molecules in the extract called the “punicalagin, punicalin and ellagic acid”, also show effects against hepatitis C virus (HCV). Pomegranate peel extracts (PoPEx) have also shown effects against the influenza virus by preventing virus entry and transcription of the RNA.
This study targeted four major ellagitannin members present in PoPEx, “punicalagin, punicalin, ellagic acid, and gallic acid,” to see their efficacy against SARS-CoV-2 in lab models (in silico tools).
The researchers tested the binding affinities of ellagic acid, gallic acid, punicalagin, and punicalin on four protein targets that could allow entry of the virus into the host cell. The results of this study showed that constituents of pomegranate peel extracts such as punicalagin and punicalin show significant potential in interacting with the selected protein targets and thus could possibly prevent the viral entry into the host cell.
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