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Cow antibodies be key to effective HIV/AIDS Vaccine

Cow antibodies be key to effective HIV/AIDS Vaccine

A new study shows that cows' quick immune response could hold the key to creating a human HIV vaccine.

Immunogens And Antigens
Scientists supported by the National Institutes of Health (NIH) just made a significant step toward hopefully developing an effective HIV vaccine after an experiment that involved cows. What they found was that unlike humans, cows actually have the capability to develop HIV neutralizing antibodies (bNAbs) much faster than humans can.

What researchers essentially did was to inject four calves with proteins designed to mimic the ones on the surface of HIV in hopes of inducing an immune response. In a matter of 35 to 50 days, all four calves have already developed bNAbs.

Compared to HIV-infected humans in whom only 10 to 20 percent develop bNAbs and only after two years of infection, this feat by the calves is truly groundbreaking.

What's more, one of the cows' immune response was able to neutralize 20 percent of the HIV strain in 42 days, while another was able to neutralize a staggering 96 percent of the HIV strain within 381 days.

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